Institute of Pharmacy

Pharmaceutical Chemistry



Department of Pharmaceutical Chemistry is an integral part of pharmacy education programme, as it covers several aspects of new drug discovery and development in collaboration with the other four departments of the institute.

Infrastructure

Department of Pharmaceutical Chemistry has two postgraduate and two undergraduate laboratories. The laboratories are designed and equipped with several state of the art technologies including central ventilation system and very sophisticated fume hoods attached with nitrogen, vacuum and water supply. Emergency shower rooms are provided in each laboratory with a special focus on the safety of the workforce. The laboratories are spacious and ventilated having adequate space for students to carry out experimental work smoothly.  

In the research laboratory we have various instruments essential for routine smooth conduct of the experiments like Precision Digital Balance, Multimagnetic  Stirrer, Rotamantle, Constant Temperature Water-bath, Digital Mechanical Stirrers, High Speed Centrifuge, Hot Air Oven and advanced instruments to facilitate the research work, which include:

  • Microwave Synthesizer
  • Microwave Oven
  • Fourier Transform Infra-red  (IR) Spectrophotometer
  • IR-Microscope
  • Flash Chromatography (MPLC)
  • Gel Electrophoresis
  • UV-near IR spectrophotometer
  • Raman Spectrophotometer
  • Rotary Vacuum Evaporator
  • Precision Melting Point Apparatus
  • Cryogenic Bath
  • Software for Computational Chemistry i.e. 3D Modeling, Drug Design, Molecular Modeling
  • GROMACS 5.0 with LINUX Work Station
  • SYBYL X 1.2 software for Computer Aided Drug Design.
  • GOLD Suit Software
  • Digital Polorimeter

Curriculum

Undergraduate Programme

The subjects covered, as a part of undergraduate teaching, are Pharmaceutical Chemistry, Inorganic and Nuclear Medicinal Chemistry, Organic Chemistry, Pharmaceutical Biochemistry and Medicinal Chemistry. Pharmaceutical Chemistry involves the study of the physicochemical properties of Chemical Substances, Types of Intermolecular Interactions and Radioactivity. Inorganic and Nuclear Medicinal Chemistry deals with the inorganic drug molecules for the treatment of several disease conditions, while nuclear chemistry deals with the chemistry of radiopharmaceuticals, their production, preparation, compounding, quality control and use of radionuclides as diagnostic aid or as a therapeutic agent. Organic Chemistry forms the basis of medicinal chemistry and it includes the fundamental chemistry of the various functional groups as well as stereochemistry and the chemistry of heterocyclic molecules. Medicinal Chemistry deals with different sources of drugs, mechanism of action, synthetic route and pharmacokinetic properties of present day drugs. It also covers combinatorial chemistry and computational chemistry which includes the theoretical aspects of drug designing that is 2D and 3D-QSAR, molecular modeling, docking studies and virtual screening.

Post Graduate Programme

The department is extensively involved in post graduate programme in ‘Medicinal Chemistry” This includes teaching with research oriented subjects like Advanced Organic Chemistry, Advanced Pharmaceutical Chemistry, Advanced Medicinal Chemistry (Recent Advances in Medicinal Chemistry), and Interpretation of Spectral Data. Extensive use of modern audio-visual teaching aids and molecular models make the lessons interesting and student centric. Students are also encouraged to undertake elaborate literature search in the preparation of seminars on the topics assigned to them.

Research Activities

We have students registered for Doctoral studies as well as Masters in Medicinal Chemistry. The faculty too is engaged in research for their Doctoral degrees. In the future, the department is planning to extend its wings extensively in the areas of computational chemistry, microwave assisted organic synthesis & solid phase synthesis by registering several doctorate and postgraduate students from various parts of the country.

Several students have registered for Ph.D degree in the department of Pharmaceutical Chemistry and are getting stipend from INSPIRE-DST and CSIR. Also, the department has received Major Research Project of Rs. 34 lakh from DST, Govt. of India for Liquid Phase Combinatorial Synthesis. Faculty members of the department are also working on Minor Research Projects of Rs. 8.5 lakh from GUJCOST. The department has published several papers in International Journals like European Journal of Medicinal Chemistry, PLOS, Bioorganic and Medicinal Chemistry Letters, Medicinal Research Reviews, Mini Reviews in Medicinal Chemistry, Medicinal Chemistry Research, etc. Faculty members of the department also published three patents in Indian patent. The department regularly organizes several National seminars like Recent Advances in Drug Discovery, Hands on Training in Drug Discovery Software, Workshop on Interpretation of Spectral Data, etc.